{"product_id":"regulation-of-membrane-na-k-atpase-von-sajal-chakraborti-naranjan-s-dhalla-hrsg","title":"Regulation of Membrane Na+-K+ ATPase","description":"\n                \u003cp\u003eNa\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase is either mediated by changes in intracellular Na\u003csup\u003e+\u003c\/sup\u003e concentrations that directly affect the Na\u003csup\u003e+\u003c\/sup\u003e-pump activity or by phosphorylation\/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na\u003csup\u003e+\u003c\/sup\u003e-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra\u003c\/p\u003ene domain adjacent to the isoform(s) of α-β subunits of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase. Considering the extraordinary importance of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+\u003c\/sup\u003e ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled \u003ci\u003e“Regulation of Membrane Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+\u003c\/sup\u003e ATPase”\u003c\/i\u003e for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+\u003c\/sup\u003e ATPase regulation in health and disease.\u003cp\u003e\u003c\/p\u003e\n                \u003cp\u003e\u003c\/p\u003e\n                \u003cp\u003e\u003c\/p\u003e\n                \u003cp\u003e\u003c\/p\u003e\n                \u003cp\u003e\u003c\/p\u003e\n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783319796727\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783319247489\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783319796727","offer_id":39420208250973,"sku":"9783319796727","price":160.49,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9783319247489","offer_id":28563586547805,"sku":"9783319247489","price":160.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/43dcf7de-de34-4d6b-99f4-459220ef3dd4.jpg?v=1764826287","url":"https:\/\/shop.autorenwelt.de\/products\/regulation-of-membrane-na-k-atpase-von-sajal-chakraborti-naranjan-s-dhalla-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}