{"product_id":"reaction-monitoring-in-multiphase-systems-application-of-coupled-in-situ-spectroscopic-techniques-in-organic-synthesis-von-leif-robin-knopke","title":"Reaction monitoring in multiphase systems: Application of coupled in situ spectroscopic techniques in organic synthesis","description":"\u003cp\u003eThe benefit of coupling different in situ spectroscopic methods (ATR-FTIR \/ UV-vis \/ Raman\u003c\/p\u003e\u003cp\u003espectroscopy) is exemplarily demonstrated by the means of two reactions as application\u003c\/p\u003e\u003cp\u003eexamples: the Lewis acid mediated formal [3+3] cyclocondensation reaction of a diene with a\u003c\/p\u003e\u003cp\u003eketenacetale and the heterogeneously catalysed asymmetric hydrogenation of imines. For both\u003c\/p\u003e\u003cp\u003ereactions new reactors (deep-temperature cell, probe autoclave) have been developed enabling\u003c\/p\u003e\u003cp\u003ein situ measurements under real reaction conditions\u003c\/p\u003e\u003cp\u003eFor the [3+3] cyclocondensation reaction it was demonstrated that the nature of the\u003c\/p\u003e\u003cp\u003eformed product depends on the different intermediates formed between the ketenacetal and\u003c\/p\u003e\u003cp\u003ethe acids (complexation or acid catalysed rearrangement reaction). Furthermore the\u003c\/p\u003e\u003cp\u003emechanisms of similar reactions (including other Lewis acids like AlCl3, Al2O3 and TiO2 or\u003c\/p\u003e\u003cp\u003esubstrates like N-salicylideneaniline) could be successfully elucidated.\u003c\/p\u003e\u003cp\u003eThe effectiveness of the hydrogenation depends on the specific interaction of the\u003c\/p\u003e\u003cp\u003etested ketimines with the phosphoric acid ester used as chiral modifer. This interaction is\u003c\/p\u003e\u003cp\u003emainly influenced by the used solvent and leads to the formation of a carbocation (CH3OH) or\u003c\/p\u003e\u003cp\u003ea contact ion pair in (CH2Cl2, CF3CH2OH). Furthermore, the detected strong adsorption of\u003c\/p\u003e\u003cp\u003eimines and modifier on the Pt\/Al2O3 catalyst affect their efficiency and activity in the\u003c\/p\u003e\u003cp\u003ereaction.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783954040292\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783954040292","offer_id":40125003038813,"sku":"9783954040292","price":23.6,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b34d1025-7c73-4816-9ae6-f2050210e8d7.jpg?v=1783057411","url":"https:\/\/shop.autorenwelt.de\/products\/reaction-monitoring-in-multiphase-systems-application-of-coupled-in-situ-spectroscopic-techniques-in-organic-synthesis-von-leif-robin-knopke","provider":"Autorenwelt Shop","version":"1.0","type":"link"}