{"product_id":"radiation-oncology-advances-von-soren-m-bentzen-paul-m-harari-t-rockwell-mackie-minesh-p-mehta-hrsg","title":"Radiation Oncology Advances","description":"from combining radiation with a molecular targeted agent – namely cetuximab, a recombinant mouse\/human chimeric monoclonal antibody against the Epidermal Growth Factor (EGF) receptor [4] Astsaturov, Cohen and Harari present a more indepth review of the biology of the EGF Receptor and its signaling pathway in Chap. 7 as a potential target in combination with fractionated radiotherap y for head and neck squamous cell carcinoma (HNSCC). A flurry of agents are under de velopment for targeting EGFR and in March 2006, the US Food and Drugs Administration approved cetuximab combined with radiation as a primary treatment option for patients with loco-regionally advanced HNSCC in whom chemoradiation therapy is deemed not to be an option. While blocking the EGF pathway during fractionated radiotherapy may seem an obvious strategy [5], the rationale for combining antiangiogenic and antivascular targeting agents with radiation may be less intuitive. However, recent research shows that there are several reasons why this could result in a therapeutic gain in practice. Chapter 8 is a review of this rapidly expanding field by Citrin and Camphausen. Targeted agents combined with radiation may offer new opportunities in the treatment of central nervous system malignancies, a tumor type where the outlook remains poor despite some recent progress [6]. Current attempts to overcome rad- tion resistance in these tumors on the basis of an improved understanding of their molecular biology are the topic of Chap. 9 by Chakravarti and Palanichamy.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9780387367439\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9781441942210\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9780387367439","offer_id":51789387078,"sku":"9780387367439","price":213.99,"currency_code":"EUR","in_stock":true},{"title":"Softcover - 9781441942210","offer_id":39415075962973,"sku":"9781441942210","price":117.69,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/65641406-12bc-45d4-a0a5-ed9dcc391b27.jpg?v=1775708081","url":"https:\/\/shop.autorenwelt.de\/products\/radiation-oncology-advances-von-soren-m-bentzen-paul-m-harari-t-rockwell-mackie-minesh-p-mehta-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}