{"product_id":"quantitative-studies-in-t-and-b-cell-epitope-mimicry-von-james-cavenaugh","title":"QUANTITATIVE STUDIES IN T AND B CELL EPITOPE MIMICRY","description":"\u003cp\u003eThis work describes pharmaceutical aspects of some peptide vaccines based on T and B cell epitopes, from the initial computer-aided design to their synthesis, characterization, and use in mice, and finally the results of ELISA assays.  The B cell epitopes were chosen to mimic the CDR-H3 loop of an anti-DNA antibody, intended as a model for targeting undesirable (autoimmune or cancerous) B cell clones.  These assays show the increase in cross-reactivity with their parent protein with repeated immunization.  The T cell epitope was used in a dose response study (a 300-fold range in dose) comparing the epitope, its incorporation into a multiple antigenic peptide (MAP), and its parent protein (chicken hen egg lysozyme, HEL), and controls, all fluorescently labeled.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838317915\"\u003e\u003ch3\u003eEpitope Mimicry for Peptide Vaccines\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838317915","offer_id":39469174259805,"sku":"9783838317915","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/8cb041c2-5f47-43ed-af1c-91ccaeb5f7ee.jpg?v=1757741232","url":"https:\/\/shop.autorenwelt.de\/products\/quantitative-studies-in-t-and-b-cell-epitope-mimicry-von-james-cavenaugh","provider":"Autorenwelt Shop","version":"1.0","type":"link"}