{"product_id":"pyrazolopyrimidine-derivatives-as-cyclin-dependant-kinase-inhibitors-von-phoebe-f-lamie","title":"Pyrazolopyrimidine derivatives as cyclin-dependant kinase inhibitors","description":"\u003cp\u003eThis book contains both review and synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as cycline dependent kinase inhibitors (CDKIs). Moreover, cytotoxic activity for the newly synthesized compounds were evaluated, specially on breast cancer cell line (MCF-7). The results obtained were compared with methotrexate as a reference drug. Docking study and molecular modeling were also done using MOE program. I hope this work to be helpful and a starting point for much more new compounds with better activity to help in treatment of such a big terrible disease like cancer. Author: Phoebe F. Lamie\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659792991\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659792991","offer_id":39449539706973,"sku":"9783659792991","price":76.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/116d6ed4-2ba2-4740-9111-82aa3a95725d.jpg?v=1756183054","url":"https:\/\/shop.autorenwelt.de\/products\/pyrazolopyrimidine-derivatives-as-cyclin-dependant-kinase-inhibitors-von-phoebe-f-lamie","provider":"Autorenwelt Shop","version":"1.0","type":"link"}