{"product_id":"prostate-proto-oncogene-molecular-action-von-el-hassane-sidibe","title":"Prostate Proto-Oncogene Molecular Action","description":"\u003cp\u003eMEK inhibition alone was less effective in inducing cytotoxicity than taxanes indicating that a down-regulation of activated ERK1\/2 may be necessary but is not sufficient for taxane-induced antitumoral effects. In line with this notion, we show in a xenograft mouse model that prostate cancer cells that are resistant to docetaxel overexpress activated ERK1\/2. Taken together, our findings underscore that the modulation of ERK1\/2 activation, in concert with other mechanisms, plays an important role in taxane-induced antineoplastic effects on prostate cancer cells.These results suggest at least partially nonoverlapping effects of docetaxel and androgen deprivation therapy and hence help to understand recent clinical findings. A further elucidation of the mode of action of docetaxel would have important implications to optimize current treatment strategies and biomarker development for men with metastatic prostate cancer.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786200460738\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786200460738","offer_id":39464695627869,"sku":"9786200460738","price":61.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/102f75ae-03b6-4f0e-b1ed-07c6672e0a2e.jpg?v=1757483940","url":"https:\/\/shop.autorenwelt.de\/products\/prostate-proto-oncogene-molecular-action-von-el-hassane-sidibe","provider":"Autorenwelt Shop","version":"1.0","type":"link"}