{"product_id":"prichiny-i-posledstwiq-genomnoj-nestabilnosti-pri-rake-prostaty-von-jentoni-dzhoshua","title":"Prichiny i posledstwiq genomnoj nestabil'nosti pri rake prostaty","description":"\u003cp\u003eJewolüciq raka predstatel'noj zhelezy ot normal'nogo äpiteliq cherez intraäpitelial'nuü neoplaziü predstatel'noj zhelezy k inwaziwnoj karcinome harakterizuetsq opredelennymi genomnymi anomaliqmi, kotorye preimuschestwenno woznikaüt w preneoplasticheskoj faze. Schitaetsq, chto osnownoj prichinoj ätih izmenenij qwlqetsq disfunkciq telomer. Jetot tezis proqsnqet swqz' disfunkcii telomer s markerami genomnoj nestabil'nosti, takimi kak anomalii hromosomy 8, delecii PTEN i aberracii TMPRSSS2-ERG, a takzhe ishod HPIN. Opredelqetsq ranee neraspoznannaq swqz' mezhdu dlinoj telomer w razlichnyh tipah äpiteliq predstatel'noj zhelezy i prilegaüschej stromoj, chto swidetel'stwuet o nalichii äffekta polq mikrosredy. Takim obrazom, suschestwuüt wazhnye wozmozhnosti dlq dal'nejshih issledowanij s cel'ü opredeleniq prirody bar'erow dlq razwitiq kancerogeneza predstatel'noj zhelezy, takih kak starenie, wyzwannoe onkogenami i telomerami, kotorye mogut byt' ispol'zowany dlq terapewticheskih celej. Jeto ponimanie mozhet takzhe pomoch' adaptirowat' lechenie raka prostaty, naprimer, stratifikaciü riska dlq muzhchin s HPIN i ispol'zowanie celewyh agentow.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786203367867\"\u003e\u003ch3\u003eIzuchenie mehanizmow i wliqniq genomnyh aberracij na kancerogenez prostaty\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786203367867","offer_id":46665816506693,"sku":"9786203367867","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/dd136da4-2a1a-4a84-9887-5056be0505dc.jpg?v=1759299859","url":"https:\/\/shop.autorenwelt.de\/products\/prichiny-i-posledstwiq-genomnoj-nestabilnosti-pri-rake-prostaty-von-jentoni-dzhoshua","provider":"Autorenwelt Shop","version":"1.0","type":"link"}