{"product_id":"polyomavirus-nephritis-von-meriam-khadhar-soumaya-chargui-und-david-buob","title":"Polyomavirus nephritis","description":"\u003cp\u003ePolyomavirus nephritis (PVAN) is one of the most common viral complications in renal transplantation. It is in more than 97% of cases caused by BK virus in the context of BK virus nephritis and in less than 2% caused by JC virus. PVAN leads to graft loss in 30 to 80% of cases. Early diagnosis is therefore necessary to modify the immunosuppressive treatment and avoid graft loss. The diagnosis of PVAN is histological and combines tubulo-interstitial inflammation and a viral cytopathic effect in the form of nuclear inclusions of tubular cells. Tubular cell infection can be highlighted by immunohistochemical evidence of Sv-40 viral antigen expression. PVAN has histologic similarities to acute cellular rejection, but the resulting treatments are diametrically opposed. One requires a decrease in immunosuppression, while the other requires an increase in immunosuppression, so accurate and early diagnosis is a major challenge.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786205665589\"\u003e\u003ch3\u003eIn renal transplantation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786205665589","offer_id":40919529488477,"sku":"9786205665589","price":43.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/47c364e1-4359-4966-b670-0f4d503d6ea9.jpg?v=1758781550","url":"https:\/\/shop.autorenwelt.de\/products\/polyomavirus-nephritis-von-meriam-khadhar-soumaya-chargui-und-david-buob","provider":"Autorenwelt Shop","version":"1.0","type":"link"}