{"product_id":"polymorphisms-in-some-genes-associated-with-type-1-diabetes-mellitus-von-ali-salim-al-shehmany","title":"Polymorphisms in some genes associated with type 1 diabetes mellitus","description":"\u003cp\u003eType 1 diabetes (T1DM) is an autoimmune disease characterized by immune destruction of insulin-producing pancreatic ¿ cells. This leads to dysfunctional regulation of blood glucose levels in T1DM patients. The destruction of ¿ -cells of Langerhans islets is caused by infiltration of dendritic cells, macrophages and T lymphocytes. Normally, genetic susceptibility (association) studies depend on assessing the role of genotype markers (typically SNPs) in the susceptibility to the disease of interest in a case- control or family based sample. Many genes associated with type 1 diabetes mellitus, CTLA-4, PTPN22, IL-10, IL-18, VIT-D receptor are one of the common confirmed T1DM susceptibility genes\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659756375\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659756375","offer_id":39449481936989,"sku":"9783659756375","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/cd3aaf24-59f9-4bd5-b5ae-da4659c623c0.jpg?v=1773382220","url":"https:\/\/shop.autorenwelt.de\/products\/polymorphisms-in-some-genes-associated-with-type-1-diabetes-mellitus-von-ali-salim-al-shehmany","provider":"Autorenwelt Shop","version":"1.0","type":"link"}