{"product_id":"polyamine-conjugates-for-non-viral-gene-therapy-von-moustafa-soltan","title":"Polyamine conjugates for non-viral gene therapy","description":"\u003cp\u003ePolyamines  Polyamines are naturally occurring small molecules  and are found in high concentrations particularly in  eukaryotic cells. Polyamines are often essentially  fully protonated under physiological condition and  these polycations also bind to DNA .Polyamines are  present in chromatin and are believed to be involved  in many cellular events and also to protect DNA from  damage by free radicals. It is widely believed that  gene therapy will become an efficient medicine for  the treatment of diseases such as cancer, cystic   fibrosis and for vaccination .The essential  requirements for gene delivery are the transport of  DNA through the cell membrane and ultimately to the  nucleus. Different strategies have been used for the  delivery of genetic material into target cells,  classified as viral or non viral delivery systems.  Efficient non viral formulation should be able to  deliver safely the required  DNA  across the various  cellular barriers to the nucleus.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838363172\"\u003e\u003ch3\u003epolyamine conjugates for DNA and siRNA Transfection\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838363172","offer_id":39499061428317,"sku":"9783838363172","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/24502b58-1b20-415d-9156-f53231711174.jpg?v=1759211109","url":"https:\/\/shop.autorenwelt.de\/products\/polyamine-conjugates-for-non-viral-gene-therapy-von-moustafa-soltan","provider":"Autorenwelt Shop","version":"1.0","type":"link"}