{"product_id":"phylogenetic-analysis-of-viral-quasispecies-von-patricia-buendia","title":"Phylogenetic Analysis of Viral Quasispecies","description":"\u003cp\u003eRevision with unchanged content. A new approach in the analysis of viral evolution is presented in this book, an approach that merges Phylogenetic analysis and Bioinformatic techniques. Patterns of viral evolution are inferred from serially-sampled sequence data, i.e., sequence data obtained from strains isolated at consecutive time points from a single patient or host. Traditional phylogenetic methods assume a tree-like evolutionary model, while many RNA viruses have the capacity to exchange genetic material with one another using a process called re­combination. A genealogy involving recombination is best described by a net­work structure. A more general approach was implemented in a new compu­tational tool, Sliding MinPD, one that is mindful of the sampling times of the input sequences and that reconstructs the viral evolutionary relationships in the form of a network structure with implicit representations of recombi­nation events. The underlying network organization reveals unique patterns of viral evolution and could help explain the emergence of disease-associated mutants and drug-resistant strains, with implications for patient prognosis and treatment strategies.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639452273\"\u003e\u003ch3\u003eHIV, HCV, Viral Evolution Study\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639452273","offer_id":39487682510941,"sku":"9783639452273","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9e339e1e-7852-4098-b813-594b33b31fa8.jpg?v=1772776990","url":"https:\/\/shop.autorenwelt.de\/products\/phylogenetic-analysis-of-viral-quasispecies-von-patricia-buendia","provider":"Autorenwelt Shop","version":"1.0","type":"link"}