Pharmacological Preconditioning with Opioids for Myocardial Protection: Role of Delta-Opioid Receptor Agonists

Pharmacological Preconditioning with Opioids for Myocardial Protection: Role of Delta-Opioid Receptor Agonists

von Daniel Sigg
Taschenbuch - 9783838353791
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Beschreibung

The objective of this research was to investigate the role of opioids in myocardial protection of the large mammalian heart. A porcine isolated working heart model of swine was carefully characterized and various opioid agonists were administered prior to inducing global ischemia. An acute coronary occlusion model was developed to investigate the effects of opioid preconditioning on regional ischemia, in particular infarct size, myocardial function, and arrhythmias. The results of these studies suggest a specific role of d-receptor agonists in myocardial protection in large mammalian hearts.

Details

Verlag LAP Lambert Academic Publishing
Ersterscheinung Februar 2013
Maße 220 mm x 150 mm x 12 mm
Gewicht 326 Gramm
Format Taschenbuch
ISBN-13 9783838353791
Auflage Nicht bekannt
Seiten 208

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