{"product_id":"pharmacological-investigation-of-four-synthetic-compounds-von-avijit-dey-md-hamiduzzaman-und-uttom-kumar","title":"Pharmacological investigation of four synthetic compounds","description":"\u003cp\u003eThe four synthetic compounds named Ortho-amino aniline, 2-bromo propyl amine hydrobromide, 3-bromopopyl ammonium bromide and Benzimidazole-2-thiol were evaluated for their pharmacological activity. Evaluation of anti-oxidant activity was done by DPPH free radical scavenging activity. In this investigation, the compound ortho amino aniline showed the highest free radical scavenging activity with IC50 value 0.85¿g\/ml. At the same time Benzimadazole-2-Thiol also showed strong antioxidant potential having IC50 value 4.18¿g\/ml. The cyto-toxic activity was evaluated using Brine shrimp lethality bio-assay. Among the supplied compounds only ortho amino aniline and bennzimidazole-2-thiol showed mild cyto-toxic activity compared to the positive standard Vincristine sulfate. The analgesic activity was evaluated using acetic acid induced writhing method. The compounds Benzimidazole-2-thiol and 3-bromopopyl ammonium bromide at a dose of 50 mg\/kg showed significant  analgesic activity with 37.85% and 42.85% inhibition of writhing. 3-bromopopyl ammonium bromide and Benzimidazole-2-thiol showed mild hypnotic activity. None of the compounds exhibited anti-microbial or ani-pyretic activity.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659232671\"\u003e\u003ch3\u003eo-amino aniline, 2-bromo propyl amine  hydrobromide, 3-bromo propyl  ammonium bromide and Benzimidazole-2-thiol\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659232671","offer_id":39487779078237,"sku":"9783659232671","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/73fd891f-bb52-4a99-bfaa-f89427163163.jpg?v=1769666040","url":"https:\/\/shop.autorenwelt.de\/products\/pharmacological-investigation-of-four-synthetic-compounds-von-avijit-dey-md-hamiduzzaman-und-uttom-kumar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}