{"product_id":"pharmacokinetics-and-bioavailability-of-silymarin-von-muhammad-usman-mahmood-ahmad-und-asadullah-madni","title":"PHARMACOKINETICS AND BIOAVAILABILITY OF SILYMARIN","description":"\u003cp\u003eSilymarin is a purified extract from milk thistle  (Silybum marianun (L.) Gaertn), composed of a  mixture of isomeric flavonolignans: silybin (its  main, active component), isosilybin, silydianin and  silychristin. This extract has been empirically used  as a remedy for almost 2000 years, and remains being  used as a medicine for many types of acute and  chronic liver diseases. Despite its routinely  clinical use as hepatoprotectant, the mechanisms  underlying its beneficial effects remain largely  unknown. The purpose of this study was to investigate the  pharmacokinetics and bioaequivalence of two brands  of Silymarin tablets in healthy male volunteers in  local population. Pharmacokinetic parameters were calculated by non- compartmental method using Kinetica® PK\/PD version  4.4 and MS Excel Windows professional XP. Maximum  concentration of Silymarin in plasma (Cmax), time to  these peak plasma concentrations (Tmax) and other  bioparameters (AUC0-¿, AUMC0-¿, t1\/2, Ke, MRT, Vd  and ClT) were determined.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844300048\"\u003e\u003ch3\u003eIN-VIVO KINETICS OF SILYMARIN (MILK THISTLE); A HEPATOPROTECTIVE AGENT\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844300048","offer_id":39497170124893,"sku":"9783844300048","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e75e651c-e69b-48cb-9744-537c48ff6bd6.jpg?v=1770791350","url":"https:\/\/shop.autorenwelt.de\/products\/pharmacokinetics-and-bioavailability-of-silymarin-von-muhammad-usman-mahmood-ahmad-und-asadullah-madni","provider":"Autorenwelt Shop","version":"1.0","type":"link"}