{"product_id":"parkinsons-disease-insights-into-pathogenesis-and-symptomatology-von-mona-el-banna","title":"Parkinson's Disease: Insights into Pathogenesis and Symptomatology","description":"\u003cp\u003eParkinson's disease (PD) is a common neurodegenerative disorder affecting over 10 million people worldwide, with prevalence rising with age. It is characterized by motor symptoms like bradykinesia and rigidity, and non-motor symptoms driven by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc). Key pathological features include alpha-synuclein aggregation into Lewy bodies, mitochondrial dysfunction, oxidative stress, and neuroinflammation.As PD progresses, dopamine depletion worsens, leading to advanced motor complications and non-motor impairments. Current treatments alleviate symptoms but do not prevent neurodegeneration. Understanding the mechanisms of alpha-synuclein aggregation, mitochondrial dysfunction, and neuroinflammation is essential for developing effective disease-modifying therapies.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639714111\"\u003e\u003ch3\u003eParkinson's Disease: Understanding Pathogenesis, Symptoms, and Challenges\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639714111","offer_id":54112744735045,"sku":"9783639714111","price":50.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b7545918-fb8e-406f-9fca-6421064531ca.jpg?v=1750567166","url":"https:\/\/shop.autorenwelt.de\/products\/parkinsons-disease-insights-into-pathogenesis-and-symptomatology-von-mona-el-banna","provider":"Autorenwelt Shop","version":"1.0","type":"link"}