{"product_id":"p-glycoprotein-and-the-development-of-multidrug-resistance-von-nicolae-alina","title":"P-glycoprotein and the development of multidrug resistance","description":"\u003cp\u003eThe development of drug resistance during the therapy is a major obstacle in the successful treatment of various pathologies. The in vitro studies on cell lines have shown that exposure to a single drug often leads to a cross-resistance to several other structurally and functionally unrelated compounds. This phenomenon is known as multidrug resistance (multidrug resistance, MDR). The membrane transporters play a role in the absorption, distribution and elimination of metabolic products, of ions and of most drugs. The membrane transporters include a variety of membrane proteins with different structures and functions, such as, for example, exchangers of ions and proteins from the ABC family (ATP-binding cassette). Importance of the membrane transporters appears from genetic diseases that are caused by alteration of their functions. Although the role of membrane transporters in the drug effects aroused a particular interest in the recent years, the relevant transporters remain still unknown to most drugs. Even though it is known that a specific transporter interacts with a drug, there is the possibility that the unidentified transporters to recognize the same drug.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659634499\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659634499","offer_id":39467481759837,"sku":"9783659634499","price":32.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c8e5a35a-c16d-4a5a-af92-b2ff2cdfc19f.jpg?v=1775109306","url":"https:\/\/shop.autorenwelt.de\/products\/p-glycoprotein-and-the-development-of-multidrug-resistance-von-nicolae-alina","provider":"Autorenwelt Shop","version":"1.0","type":"link"}