{"product_id":"overcoming-the-glial-scar-after-spinal-cord-injury-von-andrew-m-tan-und-joel-m-levine","title":"Overcoming The Glial Scar After Spinal Cord Injury","description":"\u003cp\u003eDamaged neurons in the CNS generally fail to regenerate after  spinal cord injury (SCI), which may be due in part to the formation  of the glial scar, a biochemical and physical barrier against axon  growth. Here we report on evidence for 3 major conclusions.  1) Antibody-mediated blockade of the growth-inhibitory NG2  molecule found in glial scars is a viable strategy to promote  sensory axon regeneration. 2) A combinatorial treatment approach  that neutralizes extrinsic inhibition and stimulates intrinsic  neuronal growth capacity is an important strategic consideration  because this method can promote long-distance, anatomically  correct axon regeneration. Accurate growth trajectory is a  prerequisite for functional recovery. 3) After SCI and growth- promoting treatments, regenerated axons remain chronically  demyelinated and exhibit pathophysiological function, similar to  that observed in cases of multiple sclerosis. This suggests the  need for further treatments designed to restore normal axon  conduction after SCI. Overall, a cure for paralysis after SCI  requires that we crudely reproduce what the developing nervous  system does naturally with precision.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838383781\"\u003e\u003ch3\u003eA Preclinical Outlook\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838383781","offer_id":39469260210269,"sku":"9783838383781","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/08f02ab2-38ae-490c-97e8-5fd39b7f4a7b.jpg?v=1769148023","url":"https:\/\/shop.autorenwelt.de\/products\/overcoming-the-glial-scar-after-spinal-cord-injury-von-andrew-m-tan-und-joel-m-levine","provider":"Autorenwelt Shop","version":"1.0","type":"link"}