{"product_id":"oro-dispersible-tablets-effect-of-superdisintegrants-von-appapurapu-ashok-kumar","title":"Oro dispersible tablets: Effect of superdisintegrants","description":"\u003cp\u003eThe purpose of this research was to develop orodispersible tablet of fluoxetine hydrochloride. Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor drug which is used in psychiatric disorder like depression. Orodispersible tablet prepared using various concentrations (1.5%, 3% \u0026amp; 4.5%) of superdisintegrates like crosscarmellose, crospovidone, sodium starch glycolate by wet granulation method \u0026amp; sublimation method. The preformulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the pre-compression parameters \u0026amp; the values were within prescribed limits. The tablets prepared by wet granulation \u0026amp; sublimation method were evaluated for physical parameters, wetting time, disintegration time, content uniformity and in vitro dissolution.Upon comparison sublimation method was showed good results for disintegration time ,wetting time \u0026amp; in vitro drug release studies because sublimation of camphor increases the porosity of the tablets. The tablets prepared with crospovidone at 4.5% concentration (FS-6) by sublimation method was found to be best suitable formulation.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659537806\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659537806","offer_id":39448946278493,"sku":"9783659537806","price":64.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/18030b0b-dd48-47a4-ab7e-7dde31bcf625.jpg?v=1770448161","url":"https:\/\/shop.autorenwelt.de\/products\/oro-dispersible-tablets-effect-of-superdisintegrants-von-appapurapu-ashok-kumar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}