{"product_id":"opening-the-gates-of-death-channels-in-mitochondria-von-vidyaramanan-ganesan","title":"Opening the gates of death: Channels in mitochondria","description":"\u003cp\u003eMitochondria are vital cell organelles which sustain cellular life by acting as energy factories in a normal cell. Under certain circumstances, mitochondria turn into the gateways to death by releasing death-inducing proteins into the cytosol. The channels in the mitochondrial outer membrane that allow the efflux of the death-inducing proteins from mitochondria into the cytosol are unknown. My graduate research work was focused on understanding the nature of these channels both structurally and functionally. I discovered that the lipid called ceramide and the protein called Bax act together to facilitate protein release from mitochondria. My work shed further insights into how ceramide forms channels. I also explored the dynamics of channel formation by Bax. I developed ionic strength as a useful diagnostic tool study Bax channel formation in vitro.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659331329\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659331329","offer_id":39448264966237,"sku":"9783659331329","price":71.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/dcdc0911-c6ce-49e3-afd9-ef9561a49154.jpg?v=1772776748","url":"https:\/\/shop.autorenwelt.de\/products\/opening-the-gates-of-death-channels-in-mitochondria-von-vidyaramanan-ganesan","provider":"Autorenwelt Shop","version":"1.0","type":"link"}