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Nowadays,the increasing numbers of heart diseases cases is very worrying although the medication technologies are always improving and moving forward.In this book,numerical modeling was used to study the effect of blood flow velocity and leaflet displacement by different shape of simplified 2D model of heart valve leaflets during cardiac cycle.Five different shapes of mitral valve leaflets and aortic valve leaflets were created and the simulation was performed by using ADINA-Fluid Structure Interaction (FSI). Ellipse shape of leaflets could be chosen as the most suitable shape among these five shapes in further study of heart valve simulation