{"product_id":"nowye-4-geteroaril-antipiriny-kak-ingibitory-dpp-iv-von-mohamed-abdalla","title":"Nowye 4-geteroaril-antipiriny kak ingibitory DPP-IV","description":"\u003cp\u003eSaharnyj diabet 2-go tipa - progressiruüschee zabolewanie, kotorym stradaet pochti 8,3% naseleniq planety. Nesmotrq na nalichie shirokogo spektra peroral'nyh gipoglikemicheskih preparatow, tol'ko 36% pacientow dostigaüt dolzhnogo glikemicheskogo kontrolq. DPP-IV, obladaüschij nizkim riskom gipoglikemii, priwlek wnimanie himikow-medikow w kachestwe nowoj misheni dlq peroral'nyh gipoglikemicheskih preparatow. V dannom doklade polucheno weduschee soedinenie 1 s antipirinowym karkasom i rasschitan rezhim ego swqzywaniq. Neskol'ko proizwodnyh s mostikowymi azotistymi geterociklami byli sintezirowany po mnogokomponentnoj reakcii w uslowiqh kontroliruemogo mikrowolnowogo nagrewa. Prowedena ocenka antidiabeticheskoj aktiwnosti w otnoshenii belka DPP-IV i srawnenie s sitagliptinom. Soedineniq s azotistymi mostikami malogo i srednego razmera byli sopostawimy s sitagliptinom po ingibiruüschej aktiwnosti w otnoshenii belka DPP-IV, chto, wozmozhno, swqzano s wozdejstwiem na Glu203 i Glu204. Peroral'naq gipoglikemicheskaq aktiwnost' soedinenij s submikromolqrnymi znacheniqmi IC50 byla dopolnitel'no ocenena na modeli myshej-diabetikow.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786206249818\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786206249818","offer_id":46906350436677,"sku":"9786206249818","price":19.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/d1049287-daec-4b15-8f39-1784b8f9763d.jpg?v=1758694675","url":"https:\/\/shop.autorenwelt.de\/products\/nowye-4-geteroaril-antipiriny-kak-ingibitory-dpp-iv-von-mohamed-abdalla","provider":"Autorenwelt Shop","version":"1.0","type":"link"}