{"product_id":"novel-syntheses-of-nitrogen-heterocycles-from-isocyanides-von-alexander-lygin","title":"Novel Syntheses of Nitrogen Heterocycles from Isocyanides","description":"\u003cp\u003eThe direct copper(I)-catalyzed synthesis of oligosubstituted pyrroles from substituted methyl isocyanides and acceptor-substituted acetylenes as well as copper(I)-mediated route to pyrroles from substituted methyl isocyanides and non-activated terminal acetylenes have been investigated. 2-Substituted phenyl isocyanides were obtained by trapping of generated in situ ortho-lithiophenyl isocyanide with electrophiles. This strategy has been effectively employed for the new synthesis of substituted 3H-quinazolin-4-ones (-thiones) including the naturally occurring alkaloids deoxyvasicinone and tryptanthrine. The reactions of ortho-lithiophenyl isocyanide and other ortho-lithiohetaryl isocyanides with aldehydes, ketones, and carbon dioxide have been investigated in detail. Two novel rearrangements of the intermediate 2-lithio-4H-3,1-benzoxazines have been disclosed. A novel copper-catalyzed synthesis of benzimidazoles from ortho-bromoaryl isocyanides and primary amines has been developed.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838117546\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783838117546","offer_id":39456931938397,"sku":"9783838117546","price":79.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e27d91df-6371-46b0-ae6e-76ef7a87f328.jpg?v=1777962318","url":"https:\/\/shop.autorenwelt.de\/products\/novel-syntheses-of-nitrogen-heterocycles-from-isocyanides-von-alexander-lygin","provider":"Autorenwelt Shop","version":"1.0","type":"link"}