{"product_id":"novel-gastroretentive-dosage-forms-von-eytan-a-klausner","title":"Novel Gastroretentive Dosage Forms","description":"\u003cp\u003eA gastroretentive dosage form (GRDF) is retained in  the stomach for an extended time period. Such a  dosage form would slowly release narrow absorption  window drugs absorbed predominantly in the stomach  and small intestine, to their absorption sites. This  should enhance bioavailability and reduce adverse  effects. Thus, the general objective of this  research is to broaden the therapeutic potential of  narrow absorption window drugs using novel GRDFs.  The outcomes of this work suggest that  gastroretentivity of dosage forms can be efficiently  prolonged by a combination of extending the dosage  form''s physical dimensions with the incorporation of  rigid constituents. The combination of prolonged  gastroretentivity and controlled release kinetics  significantly extended the time periods during which  the concentrations of model drugs in the blood were  considered therapeutic. In addition, this study is  the first to demonstrate the ability to enhance the  pharmacologic effects of a drug (furosemide) in  humans, using a  GRDF. This work illustrates the  prospective clinical benefits of novel GRDFs used  with drugs that have narrow absorption windows.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838352657\"\u003e\u003ch3\u003eDesign, Characterization, and Applications for Broadening the Therapeutic Potential of Narrow  Absorption Window Drugs\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838352657","offer_id":39499079975005,"sku":"9783838352657","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b84201ca-1294-45e9-8837-4eaa29d0483e.jpg?v=1773123355","url":"https:\/\/shop.autorenwelt.de\/products\/novel-gastroretentive-dosage-forms-von-eytan-a-klausner","provider":"Autorenwelt Shop","version":"1.0","type":"link"}