{"product_id":"novel-co-processed-superdisintegrants-for-sublingual-tablets-von-ankita-patel-nikita-gajera-pranav-shah","title":"Novel Co-Processed Superdisintegrants for Sublingual Tablets","description":"\u003cp\u003eEnalapril Maleate is anti-hypertensive drug and its oral bioavailability is 40%. Sublingual tablets of Enalapril Maleate were prepared to improve its bioavailability, to avoid pre-systemic metabolism and hepatic first pass elimination. Tablets were prepared by wet granulation technique using two different superdisintegrants KYRON-T-314 and INDION-414 in the different ratio (1:1, 1:2 \u0026amp; 2:1) by co-processing and physical mixing. The result showed that the formulation containing co-processed superdisintegrant in the ratio of 1:2 (CP2) showed faster disintegration, wetting, dispersion and maximum drug release. The disintegration time of optimized formulation (CP2) was upto 7 sec. The % in vitro drug release of Enalapril Maleate was 100.52 % in 3 min. Ex vivo permeation of CP2 was found to be 92.26±0.96% in 6 min. Thus, from the present work it reveals that the co-processed superdisintegrants formulation are superior to physical mixture formulation. Sublingual tablets of Enalapril Maleate gives faster drug release because of presence of superdisintegrants and may improve bioavailability of Enalapril Maleate.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659696855\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659696855","offer_id":39434474422365,"sku":"9783659696855","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b0050f81-4c56-4939-8ccd-a49bcbcbd0bb.jpg?v=1769494858","url":"https:\/\/shop.autorenwelt.de\/products\/novel-co-processed-superdisintegrants-for-sublingual-tablets-von-ankita-patel-nikita-gajera-pranav-shah","provider":"Autorenwelt Shop","version":"1.0","type":"link"}