{"product_id":"non-ionic-surfactant-vesicles-for-ophthalmic-drug-delivery-ocular-drug-delivery-system-von-bhavya-rastogi-upendra-nagaich-d-a-jain","title":"Non-Ionic Surfactant Vesicles for Ophthalmic Drug Delivery","description":"\u003cp\u003eNiosomes was developed and characterized for ocular drug delivery of diclofenac potassium. The present research study is a promising approach to improve corneal penetration and bio availability characteristics. Formulation also found to ensure a good entrapment efficiency and ocular bio availability of drug in-vivo. Niosome containing diclofenac potassium were prepared using surfactant and cholesterol in different ratio by Lipid film hydration technique. Niosomes were characterized For Entrapment efficiency, Particle size analysis, In-vitro drug release and In-vivo studies. Formulation with low cholesterol content which shown 82.1% Entrapment efficiency, 70.01% sustained release over a period of 10 h followed a non-fickian profile with zero order release profile. Scanning electron micrograph indicated that niosomes have a discrete spherical structure without aggregation. In-vivo study showed an availability of drug in aqueous humor for an extended time period even up to 8 hour and it showed a correlation with the release profile in-vitro. Niosome are considered the best as it showed good and high Entrapment efficiency and Vitro release with better bio availability.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783846589571\"\u003e\u003ch3\u003eOcular Drug Delivery System\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783846589571","offer_id":39462376931421,"sku":"9783846589571","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/1ee3e36d-cf21-43cb-b6f3-2d3afb22f211.jpg?v=1769495252","url":"https:\/\/shop.autorenwelt.de\/products\/non-ionic-surfactant-vesicles-for-ophthalmic-drug-delivery-ocular-drug-delivery-system-von-bhavya-rastogi-upendra-nagaich-d-a-jain","provider":"Autorenwelt Shop","version":"1.0","type":"link"}