{"product_id":"non-infectious-cxcr4-tropic-hiv-induces-t-cell-death-and-possibly-aids-von-catherine-kibirige-und-joseph-margolick","title":"Non-infectious CXCR4-tropic HIV induces T-Cell death and possibly AIDS","description":"\u003cp\u003eA gradual decline in CD4 T-Cells is the main hallmark  of HIV infection.  At the \"T-Cell inflection point\",  there is an accelerated CD4 T-Cell decline and the  onset of  CD8 T-Cell decline, leading up to Aquired Immune  Deficiency Syndrome (AIDS).  Strains of HIV that can  bind the CXCR4 co-receptor emerge prior to this,  suggesting that they contribute to immune failure by  inducing death in naive, CXCR4-bearing T-Cells.   Naive T-Cells are critical for replenishing the  immune system after any kind of T-Cell loss.   Additionally, the vast majority of HIV virions  circulating during infection are defective and non- infectious.  Their effects on immune cells are not  clearly understood. In this study, primary peripheral  blood T-cells were  exposed to inactivated, non-infectious, HIV-1  virions.  The study shows that when T-cell subsets  were purified and isolated from each other, CXCR4- tropic virions induce a significantly greater decline  in the number of naive, CD4 T-cells as opposed to the  CCR5-tropic strains which initiate HIV infection  (P=0.013).  The emergence of CXCR4-utilizing HIV  virions later on during infection may therefore  contribute to the development of AIDS.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838373683\"\u003e\u003ch3\u003eNon-Infectious CXCR4-Tropic Strains of HIV can Kill Resting, Naive, T-Cells Their Emergence Coincides with AIDS Onset\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838373683","offer_id":39499077156957,"sku":"9783838373683","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e7e23ca8-6453-439b-bf0b-02375d159ddc.jpg?v=1773124421","url":"https:\/\/shop.autorenwelt.de\/products\/non-infectious-cxcr4-tropic-hiv-induces-t-cell-death-and-possibly-aids-von-catherine-kibirige-und-joseph-margolick","provider":"Autorenwelt Shop","version":"1.0","type":"link"}