{"product_id":"nodular-forms-of-goiter-with-autoimmune-thyroiditis-thyroid-adenoma-polymorphic-variants-of-genes-bcl-2-ctla-4-apo-1-fas-in-patients-with-thyroid-pathology-regarding-its-forms-von-michael-sheremet-larysa-sydorchuk-viktor-shidlovskyi","title":"Nodular forms of goiter with autoimmune thyroiditis, thyroid adenoma","description":"\u003cp\u003eAbstract To analyze the frequency of polymorphic variants of genes BCL-2, CTLA-4, APO-1 \/ Fas in patients with thyroid pathology regarding its forms: nodular goiter with autoimmune thyroiditis and thyroid adenoma. Results: Mutation of BCL-2 and CTLA-4 genes in the homozygous state among resident¿s adult population of Northern Bukovina occurs with a fre-quency 3,2-4,0%, no reliable difference between patients and healthy. Muta-tions of the gene APO-1 \/ Fas in the homozygous state are not observed. The nature of allelic distribution set: parity ratio between the main A and G minor alleles of the BCL-2 gene. A dominance of wild-allele mutation of the G-allele CTLA-4 gene 2.57 times among patients, and 3.54 times among healthy; and the prevalence of G-allele mutation of the A-allele gene Fas ¿ 9.87 times in pa-tients and 7.33 times ¿ in healthy. Conclusions: Pathology of the thyroid gland in general has unreliable chances to be inherited depending on the polymorphism of BCL-2, CTLA-4 and Fas genes in Bukovina (Western Ukraine).\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786202027199\"\u003e\u003ch3\u003ePolymorphic variants of genes BCL-2, CTLA-4, APO-1 \/ Fas in patients with thyroid pathology regarding its forms.\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786202027199","offer_id":39447524081757,"sku":"9786202027199","price":35.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9ed4bc8e-7843-4f2b-8ee6-7943e6e3008c.jpg?v=1770101818","url":"https:\/\/shop.autorenwelt.de\/products\/nodular-forms-of-goiter-with-autoimmune-thyroiditis-thyroid-adenoma-polymorphic-variants-of-genes-bcl-2-ctla-4-apo-1-fas-in-patients-with-thyroid-pathology-regarding-its-forms-von-michael-sheremet-larysa-sydorchuk-viktor-shidlovskyi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}