{"product_id":"new-aspects-in-phosphorus-chemistry-ii-von-jean-pierre-majoral-hrsg","title":"New Aspects in Phosphorus Chemistry II","description":"\u003cp\u003eStrong non-ionic bases are highly advantageous as stoichiometric reagents and as catalysts in synthetic organic chemistry owing to side reactions that f- quently occur when ionic bases such as LDA or alkali metal alkoxides are employed. A second reason that non-ionic bases are frequently more useful in these applications is that such bases are often more soluble in less polar organic solvents,particularly at low temperatures. Thirdly,non-ionic bases can provide reactive naked or tightly associated deprotonated substrate anions that are s- bilized by the relatively large,poorly solvated cations formed by the protonated base. In such cations,extensive positive charge delocalization can occur. Prior to our work on pro-azaphosphatranes of type 1 (Scheme 1),the very strong n- ionic bases utilized for organic transformations were largely confined to the nitrogenous bases shown below (Scheme 2). Scheme 1 Scheme 2 4 J. G. Verkade 2 Uses of Strong Nonionic Nitrogen Bases 2. 1 Amines One of the earliest strong non-ionic bases to make its appearance was Proton Sponge and its derivatives [1] and these systems have been reviewed [2]. More recently Proton Sponge has been used in the palladium-catalyzed arylation of 2,3-dihydrofuran [3], and it also catalyzes Knoevenagel condensations of s- strates possessing activated methylene groups [4]. Recently the synthesis of the macrocyclic tetramine below (Scheme 3) was reported [5]. The encrypted nitrogens are very basic (pK ,24.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642079009\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783540440864\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783642079009","offer_id":39436057215069,"sku":"9783642079009","price":320.99,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9783540440864","offer_id":51273962310,"sku":"9783540440864","price":320.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/6758e498-b645-48b8-918b-d871c59dbd9b.jpg?v=1746685637","url":"https:\/\/shop.autorenwelt.de\/products\/new-aspects-in-phosphorus-chemistry-ii-von-jean-pierre-majoral-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}