{"product_id":"neurotrophic-factors-and-their-receptors-von-vimal-parkash","title":"Neurotrophic Factors and Their Receptors","description":"\u003cp\u003eFour GDNF ligands (GDNF, neurturin, artemin and persephin), and mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF) protect midbrain dopaminergic neurons that degenerate in Parkinson''s disease. Each GDNF ligand binds a specific coreceptor GDNF family receptor ¿ (GFR¿), leading to the formation of a heterotetramer complex, which then interacts with receptor tyrosine kinase RET, the signalling receptor. The present work describes the structural and biochemical characterization of the GDNF-GFR¿1 complex and the MANF and CDNF proteins.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838322469\"\u003e\u003ch3\u003eThe structural and functional studies of GDNF and MANF\/CDNF family of neurotrophic factors\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838322469","offer_id":39499052187741,"sku":"9783838322469","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/fc37f79b-d227-4141-8c78-2422b13957d5.jpg?v=1758259506","url":"https:\/\/shop.autorenwelt.de\/products\/neurotrophic-factors-and-their-receptors-von-vimal-parkash","provider":"Autorenwelt Shop","version":"1.0","type":"link"}