{"product_id":"nanoparticles-for-gene-and-drug-delivery-von-katharina-ladewig","title":"Nanoparticles for Gene and Drug Delivery","description":"\u003cp\u003eTransient gene expression (TGE) in animal cells has become the  method of choice for many researchers who wish to obtain small to moderate quantities of novel complex recombinant proteins for  further functional and structural characterisation within weeks of  cDNA discovery. TGE is more cost-effective than the time- consuming establishment of stable cell clones, but a key factor in  ensuring that these transient systems have practical application is  the availability of efficient and robust transfection agents. While  chemical transfection methods currently dominate transient  systems, the underlying fundamentals such as the formation of DNA complexes or their mode of function are not fully understood and  the characteristics of the complexes and their subsequent ability to transfect cells are variable. This monograph explores i) an inorganic  nanoparticle-based transfection system, which utilizes the anion  exchange capacity of layered double hydroxides (LDHs), and ii) a  modified polyethylenimine (PEI)-based system with significantly  reduced inherent cytotoxicity, and iii) discusses generic DNA  complex structure\/property-transfection efficiency relationships for  both systems.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838358833\"\u003e\u003ch3\u003eNanoparticle-Mediated Delivery of Nucleic Acids to Mammalian Cells\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838358833","offer_id":39469197951069,"sku":"9783838358833","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/54087a57-f486-4f87-92f3-aa64bebc1573.jpg?v=1773125127","url":"https:\/\/shop.autorenwelt.de\/products\/nanoparticles-for-gene-and-drug-delivery-von-katharina-ladewig","provider":"Autorenwelt Shop","version":"1.0","type":"link"}