{"product_id":"murine-interferon-regulatory-factor-2-irf-2-and-escherichia-coli-von-krishna-prakash-und-ajeet-kumar","title":"Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli","description":"\u003cp\u003eInterferon Regulatory Factor-2 is a vertebrate transcription factor having oncogenic nature; it antagonises Interferon Regulatory Factor-1, a tumor suppressor gene, functions. Knockout mice for IRF-2 gene showed defect in B-cell lymphopoeisis, they died following LCMV (Lymphocytic Choriomeningitis Virus) infections. IRF-2 is functionally just opposite of IRF-1. Interestingly, one would have thought that as IRF-1-\/- (knock-out) mice showed lack of CD8+T cells and low cytotoxicity of NK cells, the over production of IRF-2 in mice may restore it. But it does not happen so, the reason being unknown. However, IRF-2 binds at Interferon Stimulated Response Element sequence in viral infected cell. This book is about mouse IRF-2 gene cDNA cloning and expression of chimeric protein in E.coli. This study will serve as a platform for further functional analysis of chimeric IRF-2, which is potent oncogene in aberrant conditions.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786139861019\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786139861019","offer_id":39822681440349,"sku":"9786139861019","price":49.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/d6f8e07e-2286-456d-b728-906812d2f795.jpg?v=1758088854","url":"https:\/\/shop.autorenwelt.de\/products\/murine-interferon-regulatory-factor-2-irf-2-and-escherichia-coli-von-krishna-prakash-und-ajeet-kumar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}