{"product_id":"mucoadhesive-drug-delivery-systems-using-optimized-polymer-blends-von-bhupinder-singh-und-sukhwinder-kaur","title":"Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends","description":"\u003cp\u003eThe work embodies development and systematic  optimization of oral controlled release (CR)  mucoadhesive hydrophilic matrices of atenolol  using \"Design of Experiments\". A central composite  design was used to optimize drug release profile  and bioadhesive strength. Two polymers, namely,  Carbopol 934P and sodium CMC, were taken as  synergistic factors. The 3-D response surfaces and  2-D contour plots indicated significant effect of  both the polymers on ex vivo bioadhesive strength  of tablet against porcine gastric mucosa,  diffusional release exponent and drug release  extension. The optimized drug delivery formulation  was selected by feasibility and grid searches based  on maximization of the response variables.  Validation of drug delivery optimization study  using experimental runs indicated high prognostic  ability of the chosen experimental design. Besides  unraveling the effect of the two factors on various  response variables, the study helped in finding  the \"optimized\" formulation with excellent  bioadhesive strength and extended release for 24 h,  holding immense promise for once-a-day  gastroretentive CR formulation and minimizing  fluctuations in plasma drug levels.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838394251\"\u003e\u003ch3\u003eDeveloping Gastroretentive Controlled Release  Tablet Formulations of Atenolol using Systematic \"Design of Experiments (DoE)\"\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838394251","offer_id":39498897850461,"sku":"9783838394251","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/2bb947a5-3a6e-4d0e-879b-4c16a602bdfc.jpg?v=1768976317","url":"https:\/\/shop.autorenwelt.de\/products\/mucoadhesive-drug-delivery-systems-using-optimized-polymer-blends-von-bhupinder-singh-und-sukhwinder-kaur","provider":"Autorenwelt Shop","version":"1.0","type":"link"}