{"product_id":"mtor-inhibition-for-cancer-therapy-past-present-and-future-von-monica-mita-alain-mita-eric-k-rowinsky-hrsg","title":"mTOR Inhibition for Cancer Therapy: Past, Present and Future","description":"\n                                \n                \u003cp\u003eThis book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs.  \u003c\/p\u003e\n                                \n                \u003cp\u003eOver the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compoundscurrently under evaluation. \u003c\/p\u003e\n                                \n                \u003cp\u003e\u003c\/p\u003e\n                            \n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9782817805573\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9782817804910\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9782817805573","offer_id":39423390023773,"sku":"9782817805573","price":96.29,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9782817804910","offer_id":40144888397917,"sku":"9782817804910","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/fcb6c387-fc4e-477e-aa73-5d150c4886ed.jpg?v=1775622144","url":"https:\/\/shop.autorenwelt.de\/products\/mtor-inhibition-for-cancer-therapy-past-present-and-future-von-monica-mita-alain-mita-eric-k-rowinsky-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}