{"product_id":"monocyte-nadph-oxidase-role-of-pattern-recognition-receptors-von-deena-elsori","title":"Monocyte NADPH Oxidase: Role of Pattern Recognition Receptors","description":"\u003cp\u003eActivation of the NADPH oxidase enzyme complex results in the production of the oxygen free radical, superoxide anion (O2.-). Superoxide anion is critical for host defense against fungal and bacterial pathogens and efficient immune responses; however, uncontrolled monocyte-derived O2.- may contribute to chronic inflammation and tissue injury. We have previously identified several pathways that regulate the activity of NADPH oxidase in human monocytes; however, the receptor(s) responsible for the activation of NADPH oxidase in primary human monocytes have not yet been determined. This dissertation shows that pattern recognition receptors, namely Dectin-1, is essential for regulating NADPH oxidase activity in Zymosan-activated human monocytes. In addition this book focuses on Dectin-1 downstream signaling and complex formation with intracellular signaling proteins.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783848418138\"\u003e\u003ch3\u003eAn Overview:\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783848418138","offer_id":39491279880285,"sku":"9783848418138","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5798aa27-31d7-49ae-99f9-2936fc303616.jpg?v=1759206854","url":"https:\/\/shop.autorenwelt.de\/products\/monocyte-nadph-oxidase-role-of-pattern-recognition-receptors-von-deena-elsori","provider":"Autorenwelt Shop","version":"1.0","type":"link"}