{"product_id":"modified-pnas-synthesis-and-interaction-studies-with-dna-aunps-von-gourishankar-aland","title":"Modified PNAs: Synthesis and Interaction Studies with DNA \u0026 AuNPs","description":"\u003cp\u003ePeptide nucleic acids are a new class of DNA analogues in which charged sugar-phosphate backbone of DNA is replaced by a neutral and achiral polyamide backbone. The monomeric unit consists of N-(2-aminoethyl) glycine units to which nucleobases are attached through a conformationally rigid, tertiary acetamide linker group. The design and facile synthesis of sterically constrained new analogs of PNA having gem-dimethyl substitutions on glycine is presented. They show a higher binding to DNA relative to that with isosequential RNA. This may be a structural consequence of sterically rigid gem-dimethyl group, imposing a pre-organized conformation favorable for complex formation with cDNA. In this regard, gem-dimethyl functionality need to be explored more by introducing in aminoethyl segment or aminoethyl and glycine, both segments. Also, significant stabilization of DNA:PNA hybrids occurs upon complexation with gold nanoparticles. It is shown here that the non-thiolic polyanionic DNA can act as a template for organizing lysine capped cationic gold nanoparticles into linear superstructures. These types of assemblies may have potential for creating nanowires and lithographic circuits.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659138508\"\u003e\u003ch3\u003eMaking medicines from peptide nucleic acids (PNAs) using bio-inspired chemistry\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659138508","offer_id":39487773179997,"sku":"9783659138508","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4605b455-357c-4de1-ab9d-0fd2047db81a.jpg?v=1772862977","url":"https:\/\/shop.autorenwelt.de\/products\/modified-pnas-synthesis-and-interaction-studies-with-dna-aunps-von-gourishankar-aland","provider":"Autorenwelt Shop","version":"1.0","type":"link"}