Modified PNAs: Synthesis and Interaction Studies with DNA & AuNPs: Making medicines from peptide nucleic acids (PNAs) using bio-inspired chemistry

Modified PNAs: Synthesis and Interaction Studies with DNA & AuNPs: Making medicines from peptide nucleic acids (PNAs) using bio-inspired chemistry

von Gourishankar Aland
Taschenbuch - 9783659138508
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Beschreibung

Peptide nucleic acids are a new class of DNA analogues in which charged sugar-phosphate backbone of DNA is replaced by a neutral and achiral polyamide backbone. The monomeric unit consists of N-(2-aminoethyl) glycine units to which nucleobases are attached through a conformationally rigid, tertiary acetamide linker group. The design and facile synthesis of sterically constrained new analogs of PNA having gem-dimethyl substitutions on glycine is presented. They show a higher binding to DNA relative to that with isosequential RNA. This may be a structural consequence of sterically rigid gem-dimethyl group, imposing a pre-organized conformation favorable for complex formation with cDNA. In this regard, gem-dimethyl functionality need to be explored more by introducing in aminoethyl segment or aminoethyl and glycine, both segments. Also, significant stabilization of DNA:PNA hybrids occurs upon complexation with gold nanoparticles. It is shown here that the non-thiolic polyanionic DNA can act as a template for organizing lysine capped cationic gold nanoparticles into linear superstructures. These types of assemblies may have potential for creating nanowires and lithographic circuits.

Details

Verlag LAP Lambert Academic Publishing
Ersterscheinung September 2012
Maße 220 mm x 150 mm x 20 mm
Gewicht 511 Gramm
Format Taschenbuch
ISBN-13 9783659138508
Auflage Nicht bekannt
Seiten 332

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