{"product_id":"modified-biginelli-type-reaction-with-various-metallophthalocyanines-von-naceur-hamdi","title":"Modified Biginelli-type reaction with various metallophthalocyanines","description":"\u003cp\u003eIn this study, novel phthalonitriles 3,13,14 and their corresponding metal-free 4 and metallo phthalocyanine derivatives (5,6,7,15,16,17,18) bearing differents groups were synthesized and characterized. 3,4-dihydropyrimidinones have been synthesized in good yields by a modified Biginelli-type reaction with various metallophthalocyanines 8-23 as catalysts. Among the various metallophthalocyanines studied, cobalt(II)- phthalocyanine was found to be most active for this transformation. The newly prepared compounds were characterized using elemental analyses,MS, IR, 1H\/13C NMR, and UV¿vis spectroscopy. In addition; the 3,4-dihydropyrimidinones 8-12 were investigated for anti-oxidant activities by super oxide radical; DPPH (2,2-Diphenyl-1-picrylhydrazyl); and hydroxyl radical scavenging assays; in which most of them displayed significant antioxidant activities. Furthermore; compounds 8-12 were evaluated for anti-inflammatory activity by indirect haemolytic and lipoxygenase inhibition assays and revealed good activity.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659956720\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659956720","offer_id":39450702282845,"sku":"9783659956720","price":28.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4792631b-3048-4feb-93e7-bea0d11d0544.jpg?v=1773898111","url":"https:\/\/shop.autorenwelt.de\/products\/modified-biginelli-type-reaction-with-various-metallophthalocyanines-von-naceur-hamdi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}