{"product_id":"micrornas-as-tools-in-biopharmaceutical-production-von-niall-barron-hrsg","title":"MicroRNAs as Tools in Biopharmaceutical Production","description":"\n                                \n                \u003cp\u003eFocused manuscript on the potential use\/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics\/chapters along the following lines: Intro on CHO\/bioprocessing\/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells,  miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient\/stable disregulation, Knockout.\u003c\/p\u003e\n                            \n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9789400795266\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9789400751279\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9789400795266","offer_id":39452676915293,"sku":"9789400795266","price":106.99,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9789400751279","offer_id":40570995736669,"sku":"9789400751279","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c114a7eb-06e8-48b1-b6f3-fbc3a3668e79.jpg?v=1775628821","url":"https:\/\/shop.autorenwelt.de\/products\/micrornas-as-tools-in-biopharmaceutical-production-von-niall-barron-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}