{"product_id":"microparticulate-dosage-form-for-non-steroidal-anti-inflammatory-drugs-von-tamilvanan-shunmugaperumal","title":"Microparticulate dosage form for non-steroidal anti-inflammatory drugs","description":"\u003cp\u003eIndomethacin (IMC)-and ibuprofen (IBP)-loaded  polystyrene microparticles were prepared by emulsion- solvent evaporation method from an aqueous system.  Comparing the in vitro drug release profiles  obtained from microparticles and marketed SR  products allow the selection of an optimized  formulation for IMC and IBP. Bioavailability studies  in human volunteers indicate that while no  differences among the pharmacokinetic parameters  were evidenced between the optimized and SR- formulations of IMC, all parameters except ka and ke  of the optimized IBP formulation were lower than  that those of the SR-formulation. Although  statistically significant in vitro: in vivo  correlations were observed individually for the  optimized and for the SR- formulations, values of  retard quotient (R¿), revealed an almost same and a  lower retardation for the optimized IMC and IBP  formulations, respectively. With this coverage on in  vitro and in vivo evaluation of microparticles, this  book is an essential reference for researchers in  pharmaceutical industry who develop oral  microparticulate dosage forms.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838395425\"\u003e\u003ch3\u003eIn vitro and in vivo evaluation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838395425","offer_id":39469187203165,"sku":"9783838395425","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c1d4dc83-598a-4b70-b8fb-b9914523d786.jpg?v=1769237405","url":"https:\/\/shop.autorenwelt.de\/products\/microparticulate-dosage-form-for-non-steroidal-anti-inflammatory-drugs-von-tamilvanan-shunmugaperumal","provider":"Autorenwelt Shop","version":"1.0","type":"link"}