{"product_id":"metabolic-engineering-of-basfia-succiniciproducens-for-the-production-of-carbon-three-compounds-band-7-von-jonathan-thomas-fabarius","title":"Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds (Band 7)","description":"\u003cp\u003eBeschreibung\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, ¿-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for ¿-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783736999138\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783736999138","offer_id":39766573416541,"sku":"9783736999138","price":41.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/87541e25-b604-406f-81e6-e845d0420b2e.jpg?v=1776494178","url":"https:\/\/shop.autorenwelt.de\/products\/metabolic-engineering-of-basfia-succiniciproducens-for-the-production-of-carbon-three-compounds-band-7-von-jonathan-thomas-fabarius","provider":"Autorenwelt Shop","version":"1.0","type":"link"}