{"product_id":"medicinal-chemistry-von-sunitha-n-und-appa-rao-b","title":"Medicinal chemistry","description":"\u003cp\u003eSYNTHESIS AND CHARACTERIZATION OF 3,5- DIMETHYL PYRAZOLEAIM: To synthesize 3,5- dimethyl pyrazole in the laboratory and characterize the crude and re-crystallized product.APPARATUS\/INSTRUMENT REQUIRED: Reflux condenser, round bottomed flask, beaker, glass rod, pipette, buchner funnel, filtering flask, water bath, watch glass, capillary tube, thiele¿s tube, thermometer, electronic balance, vacuum pump and filter paper.CHEMICALS REQUIRED: Acetyl acetone, hydrazine hydrate, ethyl alcohol and n-hexane\/petroleum ether.CHEMICAL REACTION: REACTION MECHANISM: PRINCIPLE: Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine. For example, acetyl acetone and hydrazine gives 3,5-dimethyl pyrazole. The enamine and imine formed undergo cyclization to yield the product.PROCEDURE: 1. Take 0.06 moles of hydrazine hydrate in a 250 ml flask.2. To this, add 25 mL of ethyl alcohol with constant stirring.3. Now place the flask in an ice-old water or ice-bath and wait for 10 minutes.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786206142058\"\u003e\u003ch3\u003elab manual\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786206142058","offer_id":40941907869789,"sku":"9786206142058","price":43.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/3e959a0d-4957-41ea-9f1c-ac2b3c0bb128.jpg?v=1777353469","url":"https:\/\/shop.autorenwelt.de\/products\/medicinal-chemistry-von-sunitha-n-und-appa-rao-b","provider":"Autorenwelt Shop","version":"1.0","type":"link"}