{"product_id":"mechanisms-of-leptin-in-breast-cancer-development-and-progression-von-candida-perera-und-ignacio-camarillo","title":"Mechanisms of Leptin in Breast Cancer Development and Progression","description":"\u003cp\u003eObesity is a recently established risk factor for  breast cancer. A characteristic of obesity is  elevated circulating levels of adipocyte-derived  hormone leptin. Evidence indicates leptin plays an  important role in breast cancer development and  progression; however the mechanisms involved are  poorly understood. Towards better defining the role  of leptin in breast cancer, herein we describe the  identification of leptin-regulated genes and  proteins in hormone responsive MCF-7 human breast  cancer cells. Leptin significantly increased the  proliferation and protein secretion in MCF-7 cells.  The effect of leptin in modulating the extracellular  environment and inhibiting apoptosis was also  determined. These data suggest leptin regulates  mammary tumor cell behavior through multiple  mechanisms. In addition to regulating mitogenic cell  signaling pathways, leptin influences mammary tumor  cell growth by regulating apoptosis,  cell cycle, secretion of autocrine\/ paracrine  factors and modulating the extracellular  environment. Identification of leptin-regulated  factors provides valuable mechanistic links into the  relationship between obesity and breast cancer.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838373331\"\u003e\u003ch3\u003eProfiling of Leptin Regulated Gene and Protein Expression in Human Breast Cancer Cells\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838373331","offer_id":39469133004893,"sku":"9783838373331","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b4e3da59-2841-4542-a461-38547d65fdfa.jpg?v=1773123625","url":"https:\/\/shop.autorenwelt.de\/products\/mechanisms-of-leptin-in-breast-cancer-development-and-progression-von-candida-perera-und-ignacio-camarillo","provider":"Autorenwelt Shop","version":"1.0","type":"link"}