{"product_id":"mechanical-models-of-confined-cell-migration-numerical-simulation-of-various-modes-of-cell-migration-von-solenne-deveraux","title":"Mechanical models of confined cell migration","description":"\u003cp\u003eCell migration in confined environments is a burning topic, since it is one of the main biological processes ruling embryogenesis, cancer metastasis or an organism immune system. Based on a previously developed cell confined migration model and the observation of micro-channels experiments, this thesis focuses of two main aspects. First, the evidence that the nucleus was capable of breaking its lamina to pass through narrow sub-nuclear constrictions led us to reconsider the way it was defined: different rheological models for the lamina and the nucleoplasm are thus used. Secondly, the confined migration model relied on an adhesion-based migration mode, while all the recent interest in cell migration through confined environments featured a compression-based migration mode in which the cell would not need to form any focal adhesions with the substrate. Hence, a new migration model is developed to describe this adhesion-free mode that mostly occurs during three-dimensional confined migration and is referred to as ¿chimneying¿, since it mimics the behavior of a rock climber in a chimney.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639872392\"\u003e\u003ch3\u003eNumerical simulation of various modes of cell migration\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783639872392","offer_id":39441539006557,"sku":"9783639872392","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/31106e8a-8a4c-484a-ac31-1d3f96ed290d.jpg?v=1775885591","url":"https:\/\/shop.autorenwelt.de\/products\/mechanical-models-of-confined-cell-migration-numerical-simulation-of-various-modes-of-cell-migration-von-solenne-deveraux","provider":"Autorenwelt Shop","version":"1.0","type":"link"}