{"product_id":"measuring-dynamic-network-interactions-von-ignacio-demarco","title":"Measuring Dynamic Network Interactions","description":"\u003cp\u003eRevision with unchanged content. The combinatorial interactions of the homeodomain protein Pit-1 with transcription factors such as C\/EBPalpha and with coregulatory proteins control the development of anterior pituitary cells. These cells fail to develop in individuals with mutations affecting the Pit-1 gene, resulting in combined pituitary hormone deficiency. The present work describes biochemical, live-cell imaging and in vivo kinetics studies that provide new insight into the dynamic network interactions inside the pituitary-cell nucleus. The findings reported here support a model where proteins move independently within the nuclear compartment and stochastically associate at specific intranuclear sites as part of metastable complexes. The probability that these proteins assemble in a particular region of the cell nucleus is related to the dominant chromatin-binding activities of the different protein partners, supporting the view that the repositioning of transcription factors and coregulators represents an important mechanism for directing changes in cell-specific gene expression. These studies also suggest an important link between the mislocalization of transcriptional complexes and disease processes.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639437393\"\u003e\u003ch3\u003ethat Control Pituitary Gene Expression\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639437393","offer_id":39489899495517,"sku":"9783639437393","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/2ab80a74-8297-4aff-b164-9cd43da2de95.jpg?v=1765002134","url":"https:\/\/shop.autorenwelt.de\/products\/measuring-dynamic-network-interactions-von-ignacio-demarco","provider":"Autorenwelt Shop","version":"1.0","type":"link"}