{"product_id":"macrophage-adipocyte-cross-talk-von-ivy-t-y-lau","title":"MACROPHAGE-ADIPOCYTE CROSS-TALK","description":"\u003cp\u003eRecent studies suggest that chronic inflammation of  adipose tissues with macrophage infiltration and  enhanced expression of pro-inflammatory cytokines  plays a significant role in the development of  obesity-related metablic disorders, such as type 2  diabetes. It was demonstrated that adenovirus- mediated over-expression of adiponectin, an anti- inflammatory insulin-sensitizing adipokine with  reduced expression in obesity, resulted in a marked  down-regulation of several inflammation-related  genes, including F4\/80 and CD68 (macrophage  markers), and monocyte chemotactic protein-1 (MCP- 1), in the white AT of 12 weeks old db\/db diabetic  mice. It was hypothesized that the reduced  expression of adiponectin might play an important  role in initiating macrophage-adipocyte cross-talk  which leads to obesity-related insulin resistance  and diabetes. This study aimed at determining the  time course and magnitude of macrophage infiltration  and inflammatory activation in AT, in relation to  changes in the AT level of adiponectin, glucose  tolerance and insulin sensitivity, in db\/db diabetic  mice.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843378093\"\u003e\u003ch3\u003eROLE OF ADIPONECTIN IN THE INITIATION OF OBESITY-RELATED INSULIN RESISTANCE AND TYPE 2 DIABETES\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843378093","offer_id":39470081802333,"sku":"9783843378093","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4b8ccdb7-81cc-4c9f-bc32-7576891f2331.jpg?v=1770878354","url":"https:\/\/shop.autorenwelt.de\/products\/macrophage-adipocyte-cross-talk-von-ivy-t-y-lau","provider":"Autorenwelt Shop","version":"1.0","type":"link"}