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This book is about Water Pollution (Microbial and Chemical) of the two lakes (i.e., Haleji and Keenjhar) of river Indus, (Pakistan). Instead of traditional style of any book on water pollution, this book comprises on qualitative and quantitative analysis of water and fish samples. Microbiological examination of water was also performed to assess the total bacterial load along with indicator organisms. In the end, the whole work was summarized, concluded and recommendations are suggested to avoid and prevent further pollution in the water bodies. This book will serve as an excellent source of knowledge for teachers, research scholars, students, NGOs and policy makers who are interested in gaining updated information regarding the important water bodies (as these are the sources of water supplies to the adjacent urban and rural areas as well as for recreational activities).