{"product_id":"klf2-a-master-regulator-of-peripheral-b-lymphocyte-homeostasis-investigations-on-the-function-of-kruppel-like-factor-2-klf2-in-b-lymphocytes-von-rebecca-winkelmann","title":"KLF2, a master regulator of peripheral B lymphocyte homeostasis","description":"\u003cp\u003eLymphocytes play a prominent role in the combat of infectious diseases. For a sufficient but limited immune response it is essential that migration and activation of lymphocytes are strictly controlled. The transcription factor KLF2 modulates T lymphocyte egress from lymphoid organs by regulating S1P1. This is not the case for B cells. Instead, KLF2 regulates homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of ß7 integrin. In mice with a B cell-specific deletion of KLF2, S1P1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring less B cells, fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow were found. Upon thymus-dependent immunization, IgG titers were diminished and antigen-specific plasma cells were absent in the bone marrow. Furthermore this study provides first evidence that KLF2 is posttranslationally phosphorylated directly or indirectly by the PI3K signaling pathway.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838125725\"\u003e\u003ch3\u003eInvestigations on the function of Krüppel-like factor 2 (KLF2) in B lymphocytes\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783838125725","offer_id":39441852399709,"sku":"9783838125725","price":53.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/2e07daf5-9be9-4dbd-bd4f-d08b6d6ca534.jpg?v=1776319900","url":"https:\/\/shop.autorenwelt.de\/products\/klf2-a-master-regulator-of-peripheral-b-lymphocyte-homeostasis-investigations-on-the-function-of-kruppel-like-factor-2-klf2-in-b-lymphocytes-von-rebecca-winkelmann","provider":"Autorenwelt Shop","version":"1.0","type":"link"}