{"product_id":"integration-of-pharmaceutical-discovery-and-development-case-histories-von-ronald-t-borchardt-roger-m-freidinger-tomi-k-sawyer-philip-l-smith-hrsg","title":"Integration of Pharmaceutical Discovery and Development","description":"In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic\/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics\/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9780306457432\"\u003e\u003ch3\u003eCase Histories\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9781441932884\"\u003e\u003ch3\u003eCase Histories\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9780306457432","offer_id":50827192838,"sku":"9780306457432","price":213.99,"currency_code":"EUR","in_stock":true},{"title":"Softcover - 9781441932884","offer_id":39414688874589,"sku":"9781441932884","price":213.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/92b8fb5b-875e-4eb7-9852-8a2d47681b9d.jpg?v=1765861570","url":"https:\/\/shop.autorenwelt.de\/products\/integration-of-pharmaceutical-discovery-and-development-case-histories-von-ronald-t-borchardt-roger-m-freidinger-tomi-k-sawyer-philip-l-smith-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}