{"product_id":"integrated-computational-approaches-in-hydrolysis-of-biomolecules-von-mehmet-ozbil","title":"Integrated Computational Approaches in Hydrolysis of Biomolecules","description":"\u003cp\u003eIn this book, we have focused on the following two projects: (1) mechanisms of peptide hydrolysis, and (2) aggregation of biomolecules. A plethora of theoretical and computational techniques; quantum mechanics, molecular dynamics, and molecular docking have been employed to accomplish the goals of these projects. The selective hydrolytic cleavage of the extremely stable peptide bond (-(O=)C-NH-) of peptides and proteins by enzymes and their analogues is required in a wide range of biological, biotechnological and industrial applications. In the first project, we have elucidated the mechanisms of peptide hydrolysis by non-metallic (beta secretase (BACE)) and metallic (insulin degrading enzyme (IDE) and neprilysin (NEP)) enzymes and the synthetic analogues of metallo-enzymes. In addition, mechanisms of activation of IDE through small molecules and alteration in substrate specificity of NEP have been investigated. The aggregation of biomolecules has been implicated in a large number of neurological disorders. In the second project, the aggregation mechanisms of insulin and Alzheimer`s amyloid beta (A¿) peptide have been studied.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639710595\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639710595","offer_id":39482397327453,"sku":"9783639710595","price":79.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/0a9653d7-d55f-4bbc-8933-da9708c2a5bc.jpg?v=1772777167","url":"https:\/\/shop.autorenwelt.de\/products\/integrated-computational-approaches-in-hydrolysis-of-biomolecules-von-mehmet-ozbil","provider":"Autorenwelt Shop","version":"1.0","type":"link"}