{"product_id":"insilico-analysis-of-docking-between-hiv-1-pr-and-derivatives-of-cui-von-dhruv-kumar","title":"Insilico analysis of Docking between HIV-1 PR and derivatives of CUI","description":"\u003cp\u003eHIV-1 Proteases (PR) are an enzyme which cleaves the  long HIV polyprotein into small functional peptide  fragment. These small fragments again terminate into  mature HIV. Inhibition of cleavage of poly protein  into small peptide fragment could prevent  regeneration of HIV. Computational docking between  HIV-1 PR and derivatives of Cyclic Urea Inhibitors  (CUIs) has provide us clue to design drug against  AIDS. Computational approaches were used to dock  ligand (CUIs) with HIV-1 PR to stop cleavage. CUIs  are seven-member ring structure of cyclic urea  compound. It incorporates the hydrogen-bonding  equivalents of an enzyme-bound water molecule into a  low molecular weight. Our result suggest that some of  derivatives of CUIs binds with HIV-1 PR, which can be  stop the fuction of HIV-1 PR(cleavage of long protein  chain into small peptide fragment).Evaluation of  docking results was performed based on steric  complementarity. This can be called the best fitting  of ligand to the enzyme pocket. The following three  factors are primarily involved to influence binding  conformation between ligand and a protein.These are  binding energy,hydrogen bonding,and hydrophobic  interaction.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844384765\"\u003e\u003ch3\u003eDocking between HIV-1 proteases and cyclic urea inhibitors : A step towards drug designing against  AIDS\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844384765","offer_id":39495934738525,"sku":"9783844384765","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e358ec83-b1ef-4b49-9e4f-6a4ffdd43475.jpg?v=1757741516","url":"https:\/\/shop.autorenwelt.de\/products\/insilico-analysis-of-docking-between-hiv-1-pr-and-derivatives-of-cui-von-dhruv-kumar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}